Sangesland, M., Li, N., Tsybovsky, Y., Rodgers, M.D., Han, J., Rodriguez, A.J., Ferguson, JA., Henry, A.R., Smith, S.C., Gillespie, R.A., Liu, C., Merriam, J., Stephens, T., Williams, C., Maestle, E., Corcoran, M., Ravichandran, M., Creanga, A., Andrews, S.F., Hedestam, G.B.K., Schramm, C.A., Reed, D.S., Douek, D.C., Zhou, T., Ward, A.B., Kaneikyo, M. Submitted. Functional, Immunogenetic, and Structural Convergence in Anti-Influenza Hemagglutinin Immunity between Humans and Macaques. Cell.
Lederhofer, J., Borst, A.J., Nguyen, L., Gillespie, R.A., Williams, C.J., Maestle, E.L., Raab, J.E., Yap, C., Ellis, D., Creanga, A., Tan, H.-X., Do, T., McDermott, A.B., Le Sage, V., Andrews, S.F., Graham, B.S., Wheatley, A.K., Reed, D.S., King, N.P., Kanekiyo, M. Submitted. Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies. Nature Communications.
Mantus, G.E., Chopde, A.J., Gorman J., Cominsky, L.Y., Ourahmane, A., Creanga, A., Shimberg, G.D., Gillespie, R.A., Van Wazer, D., Zhou, T., Gajjala, S.R., Williams, C., Maestle, E., Reed, D.S., Serebryannyy, L., Costner, P., Holman, L., Casazza, J., Dropulic, L.K., McDermott, A.B., Kanekiyo, M., Andrews, S.F. 2025. Immunization with different group 2 Influenza hemagglutinin subtypes alters the cross-reactivity of the human B cell response. Sci Transl Med. 2025 Jan;17(779):eadr8373 PMID: 39742506
Kanekiyo, M.*, Gillespie, R.A., Cooper, K., Canedo, V.G., Castanha, P.M.S., Pegu, A., Yang, E.S., Treaster, L., Yun, G., Wallace, M., Kettenburg, G., Williams, C., Lundy, J., Barrick, S., O’Malley, K., Midgett, M., Lipinski, A., Corry, J., Treat, B.R., Batsche, L.O., Creanga, A., Ritter, I., Walker, R., Olsen, E., Laughlin, A., Perez, D.R., Mascola, J.R., Boritz, E.A., Loo, Y.-M., Blair, W., Esser, M., Graham, B.S., Reed, D.S.*, Barratt-Boyes, S.M.* 2025. Pre-exposure antibody prophylaxis protects macaques from severe influenza disease. Science. 2025 Jan 31;387(6733):534-541 PMID: 39883776 * - equal contribution
Le Sage, V., Werner, B.D., Merrbach, G.A., Petnuch, S.E., Reed, D.S., Moncla, L.H., Crossland, N.A., McElroy, A.K., Duprex, W.P., Lakdawala, S.S. In Press. Prior H1N1 influenza virus immunity protects against severe disease and mortality in ferrets infected with cattle H5N1 virus. Emer Inf Dis.
2024
Gopal, R., Tutuncuoglu, E., Bakalov, V., Wasserloos, K., Li, H., Lemley, D., DeVito, L.J.J., Constantinesco, N.J., Reed, D.S., McHugh, K.j., Chinnappan, B., Andreas, A.R., Maloy, A., Bain, D., Alcorn, J., Pitt, B.R., Kaynar, A.M. 2024. Zinc deficiency enhances sensitivity to influenza A associated bacterial pneumonia in mice. Physiol Rep. 2024 Jan;12(1):e15902 PMID: 38163670
Reed, D.S., McElroy, A.K., Barbeau, D.J., McMillen, C.M., Tilston-Lunel, N., Nambulli, S., Cottle, E., Gilliland Jr., T., Rannulu, H, Lundy, J., Olsen, E., O’Malley, K.J., Xia, M., Schmer, T., Hartman, A.L., Luke, T.C., England, K.A., Bausch, C., Wu, H., Sullivan, E.J., Klimstra, W.B., Duprex, W.D. 2024. No evidence for enhanced disease caused by polyclonal SARS-CoV-2 antibody in the ferret model. PLoS ONE. Jun 20;19(6):e0290909 PMID: 38900732
Connors, K.A., Chapman, N.S., McMillen, C.M., Hoehl, R.M., McGaughey, J.J., Frey, Z.D., Midgett, M., Williams, C., Reed, D.S., Crowe Jr., J.E., Hartman, A.L. 2024. Potent neutralizing human monoclonal antibodies protect from inhalational Rift Valley fever virus. JCI Insight Aug 1;9(18):e180151 PMID: 39088277.
Reed, D.S., Duprex, W.P., Lakdawala, S. 2024. Influenza H5N1 and H1N1 viruses remain infectious in unpasteurized milk on milking machinery surfaces. Emer Inf Dis. Jun 24;30(8). PMID: 38914418
Malouli, D., Tiwary, M., Gilbride, R.M., Morrow, D., Hughes, C.M., Selseth, A., Penney, T., Castanha, P., Wallace, M., Yeung, Y., Midgett, M., Williams, C., Reed, J., Yu, Y., Gao, L., Yun, G., Treaster, L., Laughlin, A., Lundy, J., Tisoncik-Go, J., Whitmore, L.S., Aye, P.P., Schiro, F., Dufour, J.P., Papen, C.R., Taher, H., Picker, L.J., Fruh, K., Gale Jr, M.G., Maness, N.J., Hanson, S.G., Barratt-Boyes, S.*, Reed, D.S.*, Sacha, J.B.* 2024. Cytomegalovirus vaccine vector-induced effector memory CD4+ T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza. Nature Commun. 2024 Jul 19;15(1):6007. doi: 10.1038/s41467-024-50345-6. PMID: 39030218 * - equal contribution
2023
Kanekiyo, M., Gillespie, R.A., Midgett, M., O’Malley, K., Williams, C., Moin, S.M., Wallace, M., Treaster, L., Cooper, K., Syeda, H., Kettenburg, G., Rannulu, H., Obadan, A., da Silva Castanha, P., Corry, J., Xia, M., Olsen, E., Perez, D., Yun, G., Graham, B.S., Barratt-Boyes, S.*, Reed, D.S.* 2023. Refined semi-lethal H5N1 influenza model through aerosolized virus infection in macaques. iScience Sep 6;26(10):107830. PMID: 37766976 * - equal contribution
Adams, L.J., Raju, S., Ma, H., Gilliland, T., Reed, D.S., Klimstra, W.B., Fremont, D.H., Diamond, M.S. 2023. Structural and functional basis of VLDLR usage by eastern equine encephalitis. Cell Dec 28:S0092-8674(23)01318-1 PMID: 38176410
2022
Kafai, N.M., Williamson, L.E., Binshtein, E., Sukopolvi-Petty, S., Gardner, C.L., Ryckman, Z.J., Liu, J., Mackin, S., Kim, A.S., Nurgun, L., Carnahan, R.H., Jung, A., Droit, L., Reed, D.S., Handley, S.A., Klimstra, W.B., Crowe Jr., J.E., Diamond, M.S. 2022. Neutralizing monoclonal antibodies protect against Venezuelan equine encephalitis virus aerosol challenge. J. Exp. Med. Apr 4;219(4):e20212532 PMID: 35297953
Corry, J., Kettenburg, G., Upadhyay A.A., Wallace, M., Marti, M.M., Wonderlich, E.R., Bissel, S.J., Goss, K., Sturgeon. T.J. Watkins, S.C., Reed. D.S., Bosinger, S.E., Barratt-Boyes, S.M. 2022. Infiltration of inflammatory macrophages and neutrophils and widespread pyroptosis in lung drive influenza lethality in nonhuman primates. PLoS Pathogens Mar 10;18(3):e1010395 PMID: 35271686
Ma, H., Albe, J., Gilliland, T., McMillen, C., Gardner, C.M., Garner, C.M., Boyles, D.A., Cottle, E.L., Dunn. M.D., Lundy, J.D., Salama, N., O’Malley, K.J., Pandrea, I., Teichert, T., Klimstra, W.B., Hartman, A.L., Reed, D.S. 2022. Long-term persistence of viral RNA and inflammation in the CNS of macaques exposed to aerosols containing Venezuelan equine encephalitis virus. PLoS Pathogens 18(6):e1009946. PMID: 35696423
Schwarz, M.M., Connors, K.A., Davoli, K.A., McMillen, C.M., Albe, J.R., Hoehl, R.M., Demers, M.J., Ganaie, S., Price, D.A., Leung, D.W., Amarasinghe, G.K., McElroy, A.K., Reed, D.S., Hartman, A.L. 2022. Rift valley fever virus infects the posterior eye and induces inflammation in a rat model of ocular disease. J. Virol. Oct 26;96(20):e0111222. doi: 10.1128/jvi.01112-22 PMID: 36194021
Gardner, C.L., Sun, C., Dunn, M.D., Gilliland, T., Trobaugh, D.W., Terada, Y., Reed, D.S., Hartman, A.L., Klimstra, W.B. 2022. In vitro and in vivo phenotypes of Venezuelan, eastern and western equine encephalitis viruses derived from cDNA clones of human isolates. Viruses Dec 20;15(1):5 PMID: 36680046
2021
Albe, J.R., Ma, H., Gilliland, T., McMillen, C.M., Gardner, C.L., Boyles, D.A., Cottle, E.L., Dunn, M.D., Lundy, J.D., O’Malley, K.J., Salama, N., Walters, A.W., Pandrea, I., Teichert, T., Klimstra, W.B.*, Reed, D.S.*, Hartman. A.L.* 2021. Physiological and immunological changes in the brain associated with severe lethal eastern equine encephalitis virus in macaques. PLoS Path * - equal contribution. PMID: 33534855
Nambulli, S., Xiang, Y., Tilston-Lunel, N., Murphy, L.J., Sang, Z., Klimstra, W., Reed, D.S., Crossland, N.A,. Shi, Y., Duprex, P.W. 2021. Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses. Science Advances May 26;7(22):eabh0319 PMID: 34039613
Frick, O.M., Livingston, V.A., Whitehouse, C.A., Norris, S.L., Alves, D. A., Reed, D.S., Nalca, A. 2021. The natural history of aerosolized Francisella tularensis infection in cynomolgus macaques. Pathogens May 13;10(5):597 PMID: 34068262
Lovchik, J.A.*, Reed, D.S.*, Hutt, J.A., Xia, F., Stevens, R.L., Modise, T., Wu, T.H. 2021. Analysis of Multiple Francisella tularensis SCHU S4 Variants Identifies a Significantly Attenuated Substrain of SCHU S4. Pathogens May 22;10(6):638 PMID: 34067337 * - equal contribution
Shoudy, L.E., Namjoshi, P., Giordano, G., Kumar, S., Bowling, J.D., Gelhaus, H.C., Conlan, J.W., Barry, E.M., Hazlett, A.J., Hazlett, B.A., Cooper, K.L., Pittman, P.R., Reed, D.S., Hazlett, K.R.O. 2021. The O-ag dependent antibody response to Francisella differentiates rodents from higher animals and can serve as a correlate of protection. Pathogens. Dec 20;10(12):1646. PMID: 34959601
2020
Ma, Henry, Lundy, J.D., Cottle, E. L., O’Malley, K.J., Trichel, A.M., Klimstra, W.B., Hartman, A.L., Reed, D.S.*, Teichert, T.* 2020. Applications of minimally invasive multimodal telemetry for continuous monitoring of brain function and intracranial pressure in macaques with acute viral encephalitis. PLoS ONE Jun 25;15(6):e0232381 * - equal contribution. PMID: 32584818
Fears, A.C., Klimstra, W.B., Duprex, P., Hartman, A., Weaver, S.C., Plante, K.C., Mirchandani, D., Plante, J.A., Aguilar, P.V., Fernández, D., Nalca A., Totura, A., Dyer, D., Kearney, B., Lackemeyer, M., Bohannon, J.K., Johnson, R., Garry, R.F., Reed, D.S.*, Roy C.J.* 2020. Persistence of Severe Acute Respiratory Syndrome Coronavirus 2 in Aerosol Suspensions. Emer Inf Dis. Jun 22;26(9) PMID: 32568661 * - equal contribution.
Klimstra, W.B., Tilston-Lunel, N.L., Nambulli, S., Boslett, J., McMillen, C.M., Gilliland, T., Dunn, M.D., Sun, C., Wheeler, S.E., Wells, A., Hartman, A.L., McElroy, A.K., Reed, D.S., Rennick L.J., Duprex, W.P. 2020. SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected, hospitalized COVID-19 patients. J. Gen. Virol. Aug 21. doi: 10.1099/jgv.0.001481 PMID: 32821033
Hartman. A.L., Nambulli, S., McMillen, C.M., White, A.G., Tilston-Lunel, N., Hartman, M.S., Albe, J.R., Cottle, E., Dunn, M. Frye, L.J., Gilliland, T., Olsen, E., O’Malley, K.J., Scwarz, M., Tomko, J.A., Xia, M., Scanga, C.A., Flynn, J.L., Klimstra, W.B., McElroy, A.K., Reed, D.S., Duprex, W.P. 2020. SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and live virus shedding from both respiratory and gastrointestinal tracts. PLoS Path. Sep 18;16(9):e1008903 PMID: 32946524
Muñoz-Fontela, C., Dowling, W.E., Funnell, S.G.P., Gsell, P.S., Balta, X.R., Albrecht, R.A., Anderson, H., Baric, R.S., Carroll, M.W., Qin, C., Crozier, I., Dallmeier, K., de Waal, L., de Wt, E., Delang, L., Dohm, E., Duprex, W.P., Falzarano, D., Finch, C., Frieman, M.B., Graham, B.S., Gralinski, L., Guilfoyle, K., Haagmans, B.L., Hamilton, G.A., Hartman, A.L., Herfst, S., Kapstein, S.J.F., Klimstra, W., Knezevic, I., Kuhn, J., Le Grand, R., Lewis, M., Liu, W-C., Maisonnasse, P., McElroy, A.K., Munster, V., Oreshkova, N., Rasmussen, A.L., Rocha-Pereira, J., Rockx, B., Rodriguez, E., Rogers, T., Salguero, F.J., Shotsaert, M., Stittelaar, K., Thibaut, H.J., Tseng, C-T., Vergara-Alert, J., Beer, M., Brasel, T., Chan, J.F.W., Garcia-Sastre, A., Neyts, J., Perlman, S., Reed, D.S., Richt, J.A., Roy, C.J., Segales, J., Vasan, S.S. Henao-Restrepo, Barouch, D.H. 2020. Animal models of COVID-19. Nature. Sep 23. doi: 10.1038/s41586-020-2787-6. PMID:32967005
Boyles, D.A., Schwarz, M.M., Albe, J.R., McMillen, C.M., O’Malley, K.J., Reed, D.S., Hartman, A.L. 2020. Development of Rift valley fever encephalitis in rats is mediated by early infection of olfactory epithelium and neuroinvasion across the cribriform plate. J. Gen Virol Nov 24. doi: 10.1099/jgv.0.001522 PMID:33231535
2019
Trobaugh, D.W., Sun, C., Reed, D.S., Klimstra, W.B. 2019. Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants. PLoS Pathogens. Feb 11;15(2):e1007584 PMID: 30742691
O’Malley, K., Bowling, J.D., Hazlett, K.R.O., Barry, E.M., Reed, D.S. 2019. Development, characterization and standardization of a nose-only inhalation exposure system for exposure of rabbits to small particle aerosols containing Francisella tularensis. Infection & Immunity. 87(8):e00198-19 PMID: 31085702
Albe, J., Boyles, D.A., Walters, A.W., Kujawa, M.R., McMillen, C.M., Reed, D.S., Hartman, A.L. 2019. Neutrophil and macrophage influx into the central nervous system are inflammatory components of lethal Rift Valley Fever encephalitis in rats. PLoS Pathogens. Jun 20;15(6):e1007833 PMID: 31220182
Bowling, J.D., O’Malley, K.J., Klimstra, W.B., Hartman, A.L., Reed, D.S. 2019. A vibrating mesh nebulizer as an alternative to the Collison 3-jet nebulizer for infectious disease aerobiology. Applied & Environmental Microbiology. Aug 14;85(17) PMID 31253680
Ma, Henry, Lundy, J., O’Malley, K., Klimstra, W.B., Hartman, A.L., Reed, D.S. 2019. Electrocardiography Abnormalities in Macaques after Infection with Encephalitic Alphaviruses. Pathogens 8, 240; doi:10.3390/pathogens8040240 PMID: 31744158
Highlighted pre-2019 publications
O’Malley, K., Bowling, J.D., Stinson, E., Cole, K.S., Mann, B.J., Namjoshi, P., Hazlett, K.R.O.*, Barry, E.M.*, Reed, D.S.* 2018. Aerosol prime-boost vaccination with defined, attenuated mutants of type A Francisella tularensis provides strong protection in outbred rabbits against lethal aerosol challenge with virulent SCHU S4. PLoS ONE Oct 22;13(10):e0205928 PMID: 30346998 * - equal contribution
Wonderlich, E.R., Swan, Z.D., Bissel, S.J., Hartman, A.L., Carney, J.P., O’Malley, K.J., Obadan, A.O., Santos, J., Walker, R., Sturgeon, T.J., Frye Jr., L.J., Maiello, P., Scanga, C.A., Bowling, J.D., Bouwer, A.L., Duangkhae, P.A., Wiley, C.A., Flynn, J.L., Wang, J., Cole, K.S., Perez, D.R., Reed, D.S., Barratt-Boyes, S.M. 2017. Widespread virus replication in alveoli drives acute respiratory distress syndrome in aerosolized H5N1 influenza infection of macaques. J. Immunol. 198(4):1616-26 PMID 28062701
Reed, D.S., Smith, L., Cole, K.S., Santiago, A.E., Mann, B.J., Barry, E.M. 2014. Live attenuated mutants of Francisella tularensis protect rabbits against aerosol challenge with a virulent type A strain. Infect Immun 82(5):2098-2105 PMID: 24614653
Hartman, A.L., Powell, D.S., Bethel, L.M., Caroline, A.L., Schmid, R.J., Oury, T., Reed, D.S. 2014. Aerosolized Rift Valley Fever virus causes fatal encephalitis in African green monkeys and common marmosets. J. Virol. 88(4):2235-2245. PMID: 24335307
Faith, S.A., Smith, L.P., Swatland, A.S., Reed, D.S. 2012. Growth conditions and environmental factors impact aerosolization but not virulence of Francisella tularensis infection in mice. Front Cell Inf Microbio. 2(126):1-10. PMID: 23087911
Reed, D.S., Lackemeyer, M.G., Garza, N.L., Sullivan, L.J., Nichols, D. K. 2011. Aerosol exposure to Zaire ebolavirus in three nonhuman primate species: differences in disease course and clinical pathology. Micro Infect. 13(11):930-6. PMID: 21651988
Reed, D.S., Smith, L., Dunsmore, T., Trichel, A., Ortiz, L.A., Cole, K.S., Barry, E. 2011. Pneumonic tularemia in rabbits resembles the human disease as illustrated by radiographic and hematological changes after infection. PLoS One. 6(9):1-9. PMID: 21931798
Alves, D.A., Glynn, A.R., Lackemeyer, M.G., Garza, N.L., Buck, J.G., Reed, D.S. 2010. Aerosol exposure to the Angola strain of Marburg virus causes lethal viral hemorrhagic fever in cynomolgus macaques. Vet Pathol. 47(5):831-51. PMID: 20807825
Reed, D.S., Lackemeyer, M.G., Garza, N.L., Norris, S., Gamble, S., Sullivan, L.J., Lind, C.M., Raymond, J.L. 2007. Severe encephalitis in cynomolgus macaques exposed to aerosolized Eastern Equine Encephalitis virus. J Infect Dis. 196:441-450. PMID: 17597459
Geisbert T., Hensley, L.E., Larsen, T., Young, H.A., Reed, D.S., Geisbert, J.B., Scott, D.P., Kagan, E., Jahrling, P.B., and Davis, K.J. 2003. Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection. Am J Pathol 163(6):2347-2370. PMID: 14633608